D-20 | Impact of Frailty on Outcomes of Percutaneous Coronary Intervention: Insights from the Nationwide Inpatient Sample

Patients with significant coronary artery disease require percutaneous intervention (PCI). However, whether frailty has adverse outcomes in patients undergoing PCI been controversial. We investigated the impact of on who underwent PCI. reviewed National Inpatient Sample to identify that Frailty was defined using Johns Hopkins Adjusted Clinical Groups frailty-defining diagnoses indicator. Univariate and multivariate logistic regression analyses were performed determine any association between clinical outcomes. From 2017-2020, 102,324 United States, 7.3% met criteria for frailty. found frail group had longer lengths stay (10 vs 4 days, p < 0.001), higher hospitalization costs ($266k $158k, 0.001). After adjustment, we associated increased in-hospital mortality, cardiogenic shock, vasopressor requirements, need mechanical circulatory support, ventilation, incidence post-operative stroke sepsis, risk sudden cardiac death. The presence significantly stay, costs, worsening secondary These findings may suggest an alternative approach are indicated revascularization.